STUDY OF THE DIASTEREOISOMERS FORMED BETWEEN (N-ALKYL)-PIPECOLIC ACID-ANILIDES AND 2R,3R-TARTARIC ACID OR O,O'-DIBENZOYL-2R,3R-TARTARIC ACID - DO THE TARTARIC ACIDS FORM MOLECULAR-COMPLEXES, INSTEAD OF SALTS DURING OPTICAL RESOLUTIONS

摘要

It was found that during the optical resolution of (N-alkyl)-pipecolic acid-anilides by 2R,3R-tartaric acid and O,O'-dibenzoyl-2R,3R-tartaric acid that the precipitated diastereoisomer was not the salt but a diastereoisomeric complex in 8 cases from 13. The results indicate that tartaric acids may be used as general resolving agents for optical resolution of racemates even having no basic group. [References: 9]