Gastrointestinal stromal tumours (GISTs) are rare sarcomas associated with the c-kit pioto-oncogene. Because of the rarity of GISTs, and because until recently it was difficult to distinguish these tumours from other gastrointestinal mesenchymal tumours, only a few large case series have been reported that describe the clinical presentation and operative findings Gain-of-function mutations have been shown in the c-kit transmembrane receptor, which has tyro-sine kinase activity. The result can be uncontrolled cell division and neoplasia.
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