Enantioselective conjugate addition of diethylzinc to cyclic enones catalyzed by chiral copper complexes containing a new phosphorus ligand with an H-8-binaphthoxy moiety

摘要

A new chiral phosphorus amidite ligand with an H-8-binaphthoxy moiety was synthesized and applied to the copper-catalyzed asymmetric conjugate addition of diethylzinc to cyclic enones with high enantioselectivity. The results gave support to the generality of the advantage of the sterically more demanding H-8-binaphthyl backbone in biaryl chiral ligands. (C) 1998 Elsevier Science Ltd. All rights reserved. [References: 19]