Synthesis of a chiral pyridylphosphine ligand and a comparison of its rhodium complex with the structurally similar arylphosphine rhodium catalysts in the asymmetric hydrogenation of 2-(6 '-methoxy-2 '-naphthyl)propenoic acid

摘要

A chiral pyridylphosphine ligand (2R,4R)-2,4-bis[di-3'-(2',6'-dimethoxypyridyl)phosphino]pentane was synthesized. The rhodium catalyzed asymmetric hydrogenation of 2-(6'-methoxy-2'-naphthyl)propenoic acid was studied by using this ligand in comparison with the structurally similar Skewphos analogs. (C) 1998 Elsevier Science Ltd. All rights reserved. [References: 9]