An enantioselective synthesis of the core unit of the non-nucleoside reverse transcriptase inhibitor taurospongin A

摘要

An enantioselective formal synthesis of taurospongin A has been achieved. The key steps involve chelation-controlled reductions of beta-ketosulfoxide and beta-hydroxy ketone intermediates and Sharpless asymmetric epoxidation to construct the tertiary alcohol stereoselectively. (C) 2003 Elsevier Science Ltd. All rights reserved. [References: 17]