Bilateral, multicentric low-grade adenosquamous carcinomas of the breast, each arising within a separate radial scar/complex sclerosing lesion

摘要

Low grade adenosquamous carcinoma (LGASC) is a rare form of mammary carcinoma. Only a handful of reports of this tumour type have been published since Rosen and Erasberger first described the entity.1 Herein we describe a case of bilateral, multicentric LGASCs occurring in a 45-year-old woman, each arising in a radial scar or complex sclerosing lesion (CSL), necessitating mastectomy.A 45-year-old woman presented with a 2-year history of a small nodule in the right breast at the 9.30 o'clock position, 3 cm from the nipple. She was undergoing biennial screening because of a family history of a second degree relative with breast cancer in her fifth decade. In 2011 this nodule was shown to correspond on ultrasound scan to a subtle area of hypoechoic change 7 x 4 mm, whic was slightly irregular in outline and sonographically indetei ininate (Fig. 1A). Ultrasound examination of the left breast was normal. Bilateral mammograms showed no abnormality. Fine needle aspiration (FNA) was performed and slides prepared from three passes. The smears were highly cellular and contained biphasic groups of cohesive epithelial and myoepithelial cells, abundant bare nuclei and pink loose stroma and as a result were interpreted as originating from a fibroadenoma (Fig. 1B).