Antiproliferative Activity, Cell Cycle, and Apoptosis Studies of a Series of 6-Substituted 9H-Purin-9-yl-pyridinium Derivatives on a Human Cervical Carcinoma Cell Line

摘要

Physicochemical parameters are among the most relevant properties to be evaluated in the early phase of drug development. Lipophilicity is one physicochemical parameter for which early prescreening is available. Correlation analysis between lipophilicity and such biological activities as cytotoxicity, antiproliferative effects, and apoptosis has a significant impact on drug discovery, as it can be used to predict and estimate biological efficacy.