Kinase Inhibitor Drugs Edited by Rongshi Li and

摘要

Kinase inhibitors can be considered among the most exciting signaling breakthrough of this new century. Human protein kinases are intriguing drug targets, in part because they regulate a wide va-riety of signaling pathways and include over 500 distinct protein molecules. Synthetic inhibitors of protein kinases include small molecules that may be easily administered as oral therapeutic compounds. These inhibitors can rapidly, and often specifically, alter the activation state of a target kinase. Furthermore, they have significant potential in treatment of major diseases including cancer, heart disease, inflammatory disorders, diabetes, macular degeneration and neurological disorders.