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Injectable bulking agents for passive faecal incontinence

机译:用于被动性大便失禁的注射填充剂

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摘要

Faecal incontinence (FI) is a socially isolating condition that can adversely impact upon one's quality of life [1]. Depending on the definitions used, the population surveyed and the method of reporting, between 2 and 24 % of the population has some degree of FI [2]. Incontinence caused by deficiencies of the internal sphincter, regardless of the underlying cause, is characterized by reduced resting pressures and passive incontinence [3]. Unfortunately, there is little targeted therapy available for this type of incontinence [4, 5]. Aside from anti-diarrhoeals and bio-feedback which form the backbone of conservative management, the only other available options are either complex or major surgery, such as sacral nerve stimulation, artificial bowel sphincter implantation or the formation of a permanent colostomy [4, 6]. The use of injectable bulking agents, a safe and minimally invasive procedure that seems to be effective at least in the short term, is therefore inherently attractive as it fills the wide chasm between conservative and surgical management of FI.
机译:粪便失禁(FI)是一种社会隔离的状况,可能会对人的生活质量产生不利影响[1]。根据使用的定义,所调查的人群和报告方法,2%至24%的人群具有一定程度的FI [2]。由内括约肌缺陷引起的大小便失禁,无论其潜在原因是什么,其特征在于静息压力降低和被动性大小便失禁[3]。不幸的是,这种类型的失禁几乎没有针对性的疗法[4,5]。除了腹泻和生物反馈是保守治疗的基础之外,唯一可用的其他选择是复杂或大型手术,例如stimulation神经刺激,人工肠括约肌植入或永久性结肠造口术[4,6]。 ]。因此,使用注射填充剂是一种安全且微创的手术,至少在短期内有效,因此具有内在的吸引力,因为它填补了FI保守治疗和外科治疗之间的巨大空白。

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