Copper-Mediated Direct Cross-Coupling of 1,3,4-Oxadiazoles and Oxazoles with Terminal Alkynes

摘要

The transition-metal-mediated direct functionalization reactions of C-H bonds have attracted significant interest in modern organic chemistry.[1] Among them, the direct oxidative cross-coupling reactions utilizing two different C-H bonds, though difficult to achieve in a general way, are quite attractive processes, since the preactivation, such as metalation and halogenation of both coupling components, can be eliminated so that they are economically and environmentally advantageous (Scheme 1).