COMPOUND DEVELOPMENTAL EYE DISORDERS FOLLOWING INACTIVATION OF TGFp SIGNALING IN NEURAL-CREST STEM CELLS

摘要

Development of the eye depends partly on the periocular mesenchyme derived from the neural crest(NC),but the fate of NC cells in mammalian eye development and the signals coordinating the formation of ocular structures are poorly understood.Dr.Ittner(Research Laboratory for Calcium Metabolism,Zurich,Switzerland)has revealed distinct NC contributions to both anterior and posterior mesenchymal eye structures and has shown that TGFp signaling in these cells is crucial for normal eye development.