Substrate-Controlled Diastereoselectivity Switch in Catalytic Asymmetric Direct Mannich Reaction of Glycine Derivatives with Imines: From anti- to syn-a,b-Diamino Acids

摘要

The construction of multiple stereocenters in flexible acyclic molecules in a single operation with complete diastereoand enantiocontrol constitutes a central challenge within the field of asymmetric catalysis. Driven by their biological significance and synthetic value, the synthesis of optically active a,b-diamino acids[1] via catalytic asymmetric direct Mannich reaction[2] between a prochiral nitrogen pronucleophile and an imine represents a touchstone in meeting this challenge and has recently emerged as an active research area.[3]