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Peptide chemistry revolution

机译:肽化学革命

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摘要

Peptides represent a very attractive and interesting class of molecules, which stand out for adaptability to a large number of scientific applications. The field of application of peptides L is so wide that is generally indicated with "peptide science", a privilege that peptides can share with few other molecules. Peptide science is more and more emerging as a complex and interdisciplinary field, which is not only restricted to basic researches but is finally finding its place also in the development of therapeutics, diagnostics, and nanotechnologies. In fact nowadays, peptides are not exclusively used to mimic and study the activity of proteins but they are exploited in many different fields of application because of their modular structure and of their amino acid composition (1). Amino acids can be used to design complex peptide scaffolds and to influence physico-chemical properties of peptides, which can show extremely different behaviour according to their amino acid composition. Peptide science is in a never-ending evolution that is also promoting a fast revolution of the technologies necessary for peptide production. Moreover, the solid-phase revolution, a key point in peptide chemistry evolution, has been profoundly influencing and updating the way to perform organic syntheses.
机译:肽代表了非常有吸引力和有趣的一类分子,在适应大量科学应用方面脱颖而出。肽L的应用领域非常广泛,通常用“肽科学”来表示,这是肽可以与其他分子共享的特权。肽科学越来越成为一个复杂而跨学科的领域,不仅限于基础研究,而且最终在治疗,诊断和纳米技术的发展中也找到了自己的位置。实际上,如今,肽已不仅仅用于模拟和研究蛋白质的活性,而是由于其模块结构和氨基酸组成而在许多不同的应用领域中得到了利用(1)。氨基酸可用于设计复杂的肽支架并影响肽的理化性质,根据其氨基酸组成,肽的理化性质可能有很大不同。肽科学处于永无止境的发展之中,它也促进了肽生产所需技术的快速革命。此外,固相革命是肽化学发展的关键,已经深刻地影响和更新了进行有机合成的方式。

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