THERMAL ANALYSIS APPLIED TO SIMVASTATIN CHARACTERIZATION IN PHARMACEUTICAL FORMULATIONS

摘要

THERMAL ANALYSIS APPLIED TO SIMVASTATIN CHARACTERIZATION IN PHARMACEUTICAL FORMULATIONS. Thermogravimetry (TG) and differential scanning calorimetry (DSC) are used in pharmaceutical studies for drugs characterization, purity, formulations compatibility, polymorphism identification, stability evaluation, and thermal decomposition of drugs and pharmaceutical formulations. Simvastatin showed fusion at 138.5 degrees C and thermal stability up to 248 degrees C. Simvastatin was incompatible with preservative excipient butylhydroxyanisole (BHA) performing a process of crystal amorphization. The drug showed morphological polymorphism, where it has the same unit cell but with different crystal habits according to the recrystallization solvent.