Synthesis and preliminary evaluation of n-acylhydrazone compounds as antibacterial and antifungal agents [Síntese e avalia??o preliminar da atividade antibacteriana e antifúngica de derivados N-acilidraz?nicos]

摘要

We describe the synthesis and evaluation of N-acylhydrazone compounds bearing different electron-donating groups in one of its aromatic rings, obtained using a four-step synthetic route. IC50 values against pathogenic fungi and bacteria were determined by serial microdilution. Compounds showed low activity against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. By contrast, a derivative with a meta-oriented electron-donating group showed significant activity (IC50) against Candida albicans (17 mM), C. krusei (34 mM) and C. tropicalis (17 mM). Results suggest this is a promising lead-compound for synthesis of potent antifungal agents.