I am sending this Letter to the Editor concerning the association between amisulpride therapeutic dose and the occurrence of asymptomatic bradycardia. Amisulpride is a second generation antipsychotic agent that is a member of the substituted benzamides. Insomnia, anxiety, and agitation are the common side effects (occurring in 5-10%). Somnolence, constipation, nausea, vomiting, and dry mouth may occur in up to 2% of patients. Other side effects are rare and can include weight gain, acute dystonia, extrapyramidal side effects and tardive dyskinesia (Coulouvrat and Dondey-Nouvel, 1999; Isbisteretal. 2010). Cardiac disorders appear to be an extremely rare complication with amisulpride. Only a few case reports dealing with QT prolongation, hypotension, hypertension or palpitation have been published so far. Bradycardia has been reported in only one case (Pedrosa et al. 2001). That is why we present here the second case of asymptomatic bradycardia with hypotension in association with amisulpride therapy.
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