Aripiprazole augmentation in treatment-refractory obsessive-compulsive disorder.

摘要

Obsessive-compulsive disorder (OCD) responds preferentially to cognitive behavioural therapy (CBT) and to pharmacological treatment such as antidepressant drugs like serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants with a predominantly serotonergic mechanism (Math and Janardhan Reddy 2007). Approximately half of OCD patients treated with an adequate trial of SSRIs fail to fully respond and continue to exhibit significant symptoms (Bloch et al 2006).