No association of neurotensin receptor 1 gene polymorphisms with coping styles in healthy Chinese-Han individuals

摘要

Coping style is a stable trait that involves a person's abilities to overcome external and internal stressors, potentially influencing the development of stress-related psychosomatic disease (Heck et a/., 2009). Accumulating evidence suggests that genetic factors influence human coping styles (Heck et al., 2009).Neurotensin, a tridecapeptide, acts as a neurotransmitter or neuromodulator in the central nervous system (St-Gelais et al., 2006). Multiple functions of neurotensin are mediated mainly by neurotensin receptor 1 (NTR1) (St-Gelais et al, 2006). Studies have strongly suggested neurotensin and NTR1 are physiologically involved in the regulation of stress responses, and even play an important role in the neuroendocrine physiopathology of post-traumatic stress disorder (Geisler et al, 2006). However, no studies have analyzed the involvement of NTR1 in the biological mechanism of coping styles. To this end, we evaluated the association between NTRI gene single nucleotide polymorphisms (SNPs) (rs6090453, rs6011914, and rs2427422) and coping styles.