Erectile dysfunction: a weighty issue?

摘要

Erectile dysfunction (ED) is expected to affect 322 million men by 2025. A number of lifestyle factors such as smoking, obesity, alcohol consumption and lack of physical activity are linked with erectile dysfunction. We reviewed the evidence in recent studies examining the impact of weight loss upon erectile function in obese men with and without diabetes. Esposito et al. showed that weight loss through diet and increased physical activity can improve sexual function in about one-third of obese non-diabetic men with ED. Subsequently, Dallal et al. reported that the amount of surgical weight loss after gastric bypass predicted the degree of improvement in sexual function independent of improvement in glycaemic control. Wing et al. reported that weight loss in older obese diabetic subjects in the Look AHEAD trial may help in preventing the worsening of ED over time. Most recently in 2011, Khoo et al. have shown that rapid diet-induced weight loss improves sexual and endothelial function and systemic inflammation in obese diabetic men. In conclusion, the majority of recent studies show that weight loss can improve erectile function in obese men, though the beneficial effect is less profound in diabetic men.