Lack of association between endothelial nitric oxide synthase gene G894T polymorphism hypertension in the Tunisian population.

摘要

Hypertension is a multifactorial disease with genetic and environmental components. Nitric oxide (NO) is a major regulator in the cardiovascular system, it is hypothesized that abnormality in the activity of endothelial nitric oxide synthase (eNOS) might lead to NO deficiency and cause clinical hypertension (Thomas et al, 2001). We have recently shown that the 27-bp tandem repeats in intron 4 (Jemaa et al., 2009) were a significant determinant of development of hypertension in the Tunisian population.