Whole blood platelet aggregation failed to detect differences between preeclampsia and normal pregnancy.

摘要

Preeclampsia is defined as a new onset of hypertension associated with proteinuria and fluid retention detected for the first time after the 20th week of gestation. Preeclamsia, or "toxemia of pregnancy" complicates 2-8% of all pregnacies [1]. Although the causes of pregnancy-induced hypertension are not completely clear, one of the responsible mechanisms is thought to be a disorder of consumptive coagulopathy with predominant involvement of platelets [2]. However, there is an ongoing debate about whether platelet hyperactivity indeed exists during preeclampsia, and if available data are sufficient for justification of broad antiplatelet strategies. We compared whole blood platelet aggregation in patients preeclampsia with matched normal pregnant women and evaluated whether there is an association of preeclampsia severity with platelet activity.