Theoretical study on the effects of pressure-induced remodeling on geometry and mechanical non-homogeneity of conduit arteries

摘要

A structure-based mathematical model for the remodeling of arteries in response to sustained hypertension is proposed. The model is based on the concepts of volumetric growth and constitutive modeling of the arterial tissue within the framework of the constrained mixture theory. The major novel result of this study is that remodeling is associated with a local change in the mass fractions of the wall constituents that ultimately leads to mechanical non-homogeneity of the arterial wall. In the new homeostatic state that develops after a sustained increase in arterial pressure, the mass fraction of elastin decreases from the intimal side to the adventitial side of arteries, while the collagen fraction manifests an opposite trend. The results obtained are supported by some experimental observations reported in the literature.