Lentiviral Vector-Mediated Gene Transfer to Endotherial Cells Compared with Adenoviral and Retroviral Vectors

摘要

Human immunodeficiency virus(HIV,lentivirus)vector has attractive features for gene therapy,including the ability to transduce non-dividing cells and long-term transgene expression.We have already reported that lentivirus vector can transduce well-differentiated rat cardiac myocytes.Endothelial cells(EC)are an attractive target for gene therapy,both for the treatment of cardiovascular disease and for the systemic delivery of recombinant gene products directly into the circulation.