Neuromodulation and the functional dynamics of piriform cortex

摘要

Acetylcholine and norepinephrine have a number of effects at the cellular level in the piriform cortex.Acetylcholine causes a depolarization of the membrane potential of pyramidal cells and interneurons,andsuppresses the action potential frequency accommodation ofpyramidal cells.Acetylcholine also has strong effects on synaptic transmission,suppressing both excitatory and inhibitory synaptic transmission.At the same time as it suppresses synaptic transmission,acetylcholine enhances synaptic modification,as demonstrated by experiments showing enhancement of ong-term potentiation.Norepinephrine has similar effects.In this review,we discuss some of these different cellular effects and provide functional proposals for these individual effects in the context of the putative associative memory function of this structure.