Transcriptional Analysis of Rat Piriform Cortex Following Exposure to the Organophosphonate Anticholinesterase Sarin and Induction of Seizures

摘要

Organophosphorus nerve agent irreversibly inhibit acetylcholinesterase, causing a toxic buildup of acetylcholine at muscarinic and nicotinic receptors. Current medical countermeasureres to nerve agent intoxication increase survival if administered within a short period of time following exposure but may not fully prevent neurological damage. Therefore, there is a need to discover drug treatments that are effective when administered after the onset of seizures and secondary responses that lead to brain injury.