Synthesis,Characterization and Crystal Structure Studies of 1-(4-Chloro-benzenesulfonyl)-piperidin-4-yl-diphenyl-methanol

摘要

1-(4-Chloro-benzenesulfonyl)-piperidin-4-yl-diphenyl-methanol was synthesized by the condensation of [piperidin-4-yl]-diphenyl-methanol with p-chlorobenzene sulfonylchloride in methylene dichloride as solvent and triethylamine as the base.The compound obtained was characterized by spectroscopic techniques and confirmed by X-ray crystallographic studies.The crystallographic data analysis reveals that the title compound crystallizes in the monoclinic space group P2_1/c with cell parameters a = 10.214(9)A,6= 11.371(5)A,c = 20.939(16)A,beta = 115.399(2)°,V= 2197(3)A~3 for Z = 4.The structure has been solved by direct methods and refined to R_1 = 0.0560 for 3658 observed reflections with I > 2 sigma(I).The piperidine ring is in a chair conformation.The geometry around the S atom is distorted from regular tetrahedron.