Discrete stochastic model for self-renewal and differentiation of progenitor cells

摘要

We propose a discrete model for self-renewal and differentiation of hematopoietic stem cells based on the notion that, in a favorable environment, the commitment of the cells to a particular pair of progeny is a stochastic event with the possibility of either self-renewal or differentiation. Regulatory mechanisms are incorporated into the model, as is diffusion of the cytokines that carry the signals for such mechanisms. The model can produce chaotic states, and is shown to be capable of predicting some key features of the experimental data.