PharmGKB summary: Very important pharmacogene information for GSTT1

摘要

GSTT1 encodes the phase II metabolizing enzyme glutathione S-transferase theta. It is located in a gene cluster with GSTT2 and GSTT2B paralogues on chromosome 22 . Molecular evolution studies suggest that GSTT or theta is the oldest of the families of GSTs as it is present in lower organisms: other GST families may have arisen from the duplication and diversification of an ancestral GSTT gene The GSTT1 protein catalyzes the conjugation of reduced glutathione to electrophilic moeities of xenobiotics, drugs, and endogenous compounds such as peroxidized lipids . The conjugated products - often after further metabolism - are more soluble, allowing them to be more readily eliminated from the body. Important pharmacological substrates include etoposide, busulfan, platinum anticancer drugs, as well as the antituberculosis drugs isoniazid, rifampicin, and pyrazinamide , and several important industrial chemicals including butadiene, dichloromethane, and trichloroethylene .