Response to the letter to the editor entitled 'Diclofenac: Increase of myocardial infarctions at low doses?' (PDS 13-0441) authored by K Brune

摘要

We thank Prof. Dr. Brune for his interest in our recently published manuscript entitled "Myocardial infarction and individual nonsteroidal anti-inflammatory drugs meta-analysis of observational stiidies."1 We would like to point to information in the paper that we believe addresses his concerns on the reported dose effects for diclofenac. In our publication, we stated in the methods section "A dose-response analysis used the reported low-medium and high-dose estimates from each stiidy." In the results section, when describing the dose effects, we reported that "11 studies were describing the effect of individual NSAID dose on the risk of AMI [acute myocardial infarction]. Most studies used similar cut-off values to define low-medium and high daily doses, except for naproxen, for which definitions varied widely across stiidies.