Diclofenac: increase of myocardial infarctions at low doses?

摘要

A few months ago, an important article, widely read and intensively quoted, appeared in this journal: Varas-Lorenzo et al. 'Myocardial infarction and individual non-steroidal and inflammatory drugs meta-analysis of observational studies'. The investigation described was supported by the EMA. It refers to this article in its recent evaluation of diclofenac containing medicines and makes this article in addition to the manuscript published by Baigent et al? the basis of their recent PRAC (Pharmacovigilance Risk Assessment Committee) recommendations (EMA/ 353084/2013). indeed, the study deserves specific attention: It appears especially credible since it has been funded by European governmental organizations and not by drug industry. For the same reason, it deserves scrutiny and caution.