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High-fat feeding and staphylococcus intermedius infection impair beta cell function and insulin sensitivity in mongrel dogs

机译:高脂喂养和中间葡萄球菌感染损害杂种犬的β细胞功能和胰岛素敏感性

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As obesity is a state of low-grade inflammation, we aimed to investigate the combined effect of high-fat diet and bacterial infection on β-cell function and insulin sensitivity in dogs. We used 20 healthy, male, mongrel dogs randomly divided into four groups: control group—healthy, non-obese dogs; infected group—non-obese dogs with experimentally induced infection (Staphylococcus intermedius); obese group—obese dogs (after 90 day high-fat diet) and obese-infected group—obese dogs with experimentally induced infection (Staphylococcus intermedius). To evaluate insulin sensitivity and β-cell function an intravenous glucose tolerance test (IVGTT) was performed. Plasma insulin increased in all group after glucose infusion. The lowest values were found in obese-infected group. Blood glucose also increased on 3 min after glucose infusion and then gradually decreased. In obese-infected group glucose concentration on 30 min was still significantly higher than initial levels, while in other groups glucose concentration returned to the initial values. The lowest rate of glucose elimination was found in infected group. In dogs of obese group and obese-infected group AUCins 0–60 min was lower compared to controls. AUCglucose 0–60 min values were lowest in infected group, while in obese-infectd group values were the highest. Levels of ∆I/∆G in dogs of obese-infected group were significantly lower compared to controls and infected group. In conclusion, these results reveal that infection in obese dogs leads to impaired glucose tolerance, which is result of impairment in both insulin secretion and insulin sensitivity.
机译:由于肥胖是低度炎症的一种状态,因此我们旨在研究高脂饮食和细菌感染对犬β细胞功能和胰岛素敏感性的综合影响。我们使用了20只健康的雄性杂种狗,将其随机分为四组:对照组-健康的非肥胖狗;对照组:健康的非肥胖狗。感染组—实验诱导感染的非肥胖狗(中间葡萄球菌);肥胖组-肥胖犬(90天高脂饮食后)和肥胖感染组-肥胖犬经实验诱导的感染(中间葡萄球菌)。为了评估胰岛素敏感性和β细胞功能,进行了静脉葡萄糖耐量试验(IVGTT)。葡萄糖输注后各组血浆胰岛素均升高。肥胖感染组最低。葡萄糖输注后3分钟血糖也升高,然后逐渐降低。在肥胖感染组中,葡萄糖浓度在30分钟时仍显着高于初始水平,而在其他组中,葡萄糖浓度恢复到初始值。感染组的葡萄糖清除率最低。肥胖组和肥胖感染组的狗在0-60分钟内的AUC 低于对照组。感染组的AUC 葡萄糖0-60 min 值最低,而肥胖组则最高。与对照组和感染组相比,肥胖感染组犬的∆I / ∆G水平显着降低。总之,这些结果表明,肥胖犬的感染会导致葡萄糖耐量降低,这是胰岛素分泌和胰岛素敏感性均受损的结果。

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