The Trimera mouse: generating human monoclonal antiodies and an animal model for human diseases

摘要

Monoclonal antibodies of human origin may have great therapeutic value in the tretment of cancer, autommune disorders and viral or bacterial infection. Several methods for generating human monoclonal antibodies exist; some are based on the tansplantation of a functioning human immune system into severe combined immunodeficient (scid) mice o into Trimera mice, which are mice that have been lethally irradiated and radioprotected by transplantation of bone-marrow cells from scid mice.