Cancer risk estimation from dietary arsenic, a new approach from longitudinal cohort study

摘要

Inorganic arsenic is a carcinogen and consumption in low dose may lead to cancer. We estimated the cancer risk of the participants from arsenic endemic regions of West Bengal, India. The probable cancer risk was estimated following the assessment of daily inorganic arsenic intake through drinking water and diets of 20 participants for three consecutive years who had been using low arsenic water in the Indian context (median arsenic concentration in the study Years-I, II and III were 22, 16, 13 A mu g/l respectively). Probable cancer risk of the population was 2.80 x 10(-4), 2.94 x 10(-4), 3.12 x 10(-4) in the three respective study years (Year-I, II and III); just higher than the US EPA risk level of concern. The arsenic species content of the paired raw, cooked rice and urine was estimated in the as is taken basis. The major diet component, rice contained 72-86% inorganic arsenic whereas urine contains 70% organic arsenic on an average. The cancer risk assessment has been proposed to be modified by inclusion of urine arsenic release, considering the fact of arsenic release through urine. The risk became 1.28 x 10(-5), 1.13 x 10(-5), 1.01 x 10(-5) in the study Year-I, II and III respectively, considering urinary arsenic release, attributed the consideration of urine arsenic release into probable cancer risk estimation.