Calixarene/carbon nanotubes based screen printed sensors for potentiometric determination of gentamicin sulphate in pharmaceutical preparations and spiked surface water samples

摘要

Sensitive disposable sensors have been introduced for potentiometric determination of gentamicin sul phate (GNS) based on multi-walled carbon nanotubes-polyvinyl chloride (MWNTs-PVC) composite in presence of calixarene as a molecular recognition element The proposed sensors showed remarkable selectivity and sensitivity in the GNS concentration range from 10~7 to 10~(-2)molL~(-1) with Nernstian slope 30.5 ± 0.4 mV decade~(-1) and detection limit of 7.5 × 10~(-8) mol L~(-1). Modification with carbon nano tubes improved the sensors performance was through promotion of the electron-transfer processes and enhancing the stability of potential reading, response time, and shelf lifetime of sensors. The proposed method has been applied for the potentiometric assay of GNS in different dosage forms and spiked surface water samples with average recoveries agreeable with the reported official method.