Synthesis and Pharmacological Evaluation of New 2-Substituted-5-{2-[(2-halobenzyl)thio)phenyl}-1,3,4-oxadiazoles as Anticonvulsant Agents

Afshin Zarghi; Samaneh Hamedi; Fatemeh Tootooni; Behzad Amini; Behrang Sharifi; Mehrdad Faizi; Seyed Abbas Tabatabai; Abbas Shafiee

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Synthesis and Pharmacological Evaluation of New 2-Substituted-5-{2-[(2-halobenzyl)thio)phenyl}-1,3,4-oxadiazoles as Anticonvulsant Agents

机译：新型2-取代的5- {2-[（（2-卤代苄基）硫基）苯基} -1,3,4-恶二唑类化合物的合成及药理学评价

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摘要

benzodiazepine antagonist, which establishes the involvement of benzodiazepine receptors in these effects.

机译：苯二氮卓拮抗剂，可确定苯二氮卓受体参与这些作用。

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来源
《Scientia pharmaceutica 》 |2008年第2期| p.185-201| 共17页
作者
Afshin Zarghi; Samaneh Hamedi; Fatemeh Tootooni; Behzad Amini; Behrang Sharifi; Mehrdad Faizi; Seyed Abbas Tabatabai; Abbas Shafiee;
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作者单位

Department of Medicinal Chemistry, Faculty of Pharmacy,Shahid Beheshti University (M.C), Tehran, Iran;

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原文格式 PDF
正文语种 eng
中图分类药学 ;
关键词
benzodiazepine receptor; 1; 3; 4-oxadiazoles; anticonvulsant; SAR;

机译：苯二氮卓受体;1;3;4-恶二唑;抗惊厥药;SAR;

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专利

1. Design and synthesis of new 2-substituted-5-(2-(2-halobenzyloxy)phenyl)-1,3,4-oxadiazoles as anticonvulsant agents. [J] . Zarghi A, Hajimahdi Z, Mohebbi S, Chemical and Pharmaceutical Bulletin . 2008 ,第4期

机译：新的2-取代的-5-（2-（2-卤代苄氧基）苯基）-1,3,4-恶二唑的设计与合成。
2. Synthesis and anticonvulsant activity of new 2-substituted-5- (2-(2-fluorophenoxy)phenyl)-1,3,4-oxadiazoles and 1,2,4-triazoles. [J] . Almasirad A, Tabatabai SA, Faizi M, Bioorganic and Medicinal Chemistry Letters . 2004 ,第24期

机译：新的2-取代的5-（2-（2-（2-氟苯氧基）苯基）-1,3,4-恶二唑和1,2,4-三唑的合成及其抗惊厥活性。
3. Synthesis and Pharmacological Evaluation of a Novel Series of 2-((2-Aryl thiazol-4-yl)methyl)-5-(alkyl/alkylnitrile thio)-1,3,4-oxadiazole Derivatives as Possible Antifungal Agents [J] . Shelke Shivaji H., Mhaske Pravin C., Kasam Sridhar Kumar, Journal of Heterocyclic Chemistry: The International Journal of Heterocyclic Chemistry . 2014 ,第6期

机译：新型2-（（2-芳基噻唑-4-基）甲基）-5-（烷基/烷基腈硫基）-1,3,4-恶二唑衍生物的合成及药理学评价
4. Study on the Interaction of fluorescent probe 2-(2'-Chloro phenyl)-5-(2'- hydroxyl phenyl)1,3,4-oxadiazole with DNA [C] . Ding Mei, Lei Yingjie, Xu Fang, International Conference on Advanced Engineering Materials and Technology . 2011

机译：荧光探针2-（2'-氯苯基）-5-（2'-羟基苯基）1,3,4-二氧化氮与DNA的相互作用研究
5. Part I: Extension of 1,3,4-oxadiazole chemistry: Studies toward the total synthesis of aspidospermidine. Part II: Progress toward the total synthesis of rebeccamycin [D] . Tao, Houchao 2007

机译：第一部分：1,3,4-恶二唑化学反应的扩展：研究了aspsperspermidine的总合成。第二部分：瑞贝卡霉素全合成的进展
6. 2-(5-Bromothiophen-2-yl)-5-[5-(10-ethylphenothiazin-3-yl)thiophen-2-yl]-1,3,4-oxadiazole [O] . Yu-Zhen Pan, You-Gui Wang, Jian-Hui Liu, 2015

机译：2-（5-溴噻吩并-2-苯基）-5- [5-（10-乙基噻吩并嗪-3-基）噻吩-2-基] -1,3,4-恶二唑
7. Design and Synthesis of New 2-Substituted-5-2-(2-halobenzyloxy)phenyl-1,3,4-oxadiazoles as Anticonvulsant Agents [O] . Afshin Zarghi, Zahra Hajimahdi, Shohreh Mohebbi, 2008

机译：新的2取代 - 5- 2-（2-卤代氧基）苯基 -1,3,4-二唑的设计与合成作为抗惊厥药剂

Synthesis and Pharmacological Evaluation of New 2-Substituted-5-{2-[(2-halobenzyl)thio)phenyl}-1,3,4-oxadiazoles as Anticonvulsant Agents

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