Nod2-Dependent Regulation of Innate and Adaptive Immunity in the Intestinal Tract

摘要

The gene encoding the Nod2 protein is frequently mutated in Crohn's disease (CD) patients, although the physiological function of Nod2 in the intestine remains elusive. Here we show that protective immunity mediated by NodZ recognition of bacterial muramyl dipeptide is abolished in NodZ-deficient mice. These animab are susceptible to bacterial infection via the oral route but not through intravenous or peritoneal delivery. Nod2 is required for the expression of a subgroup of intestinal anti-microbial peptides, known as cryptdins. The NodZ protein is thus a critical regulator of bacterial immunity within the intestine, providing a possible mechanism for Nod2 mutations in CD.