• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Science >Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span
【24h】

Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

机译：核糖体蛋白S6激酶1信号调节哺乳动物的寿命。

获取原文
获取原文并翻译 | 示例
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Caloric restriction (CR) protects against aging and disease, but the mechanisms by which this affects mammalian life span are unclear. We show in mice that deletion of ribosomal S6 protein kinase 1 (S6K1), a component of the nutrient-responsive mTOR (mammalian target of rapamycin) signaling pathway, led to increased life span and resistance to age-related pathologies, such as bone, immune, and motor dysfunction and loss of insulin sensitivity. Deletion of S6K1 induced gene expression patterns similar to those seen in CR or with pharmacological activation of adenosine monophosphate (AMP)-activated protein kinase (AMPK), a conserved regulator of the metabolic response to CR. Our results demonstrate that S6K1 influences healthy mammalian life span and suggest that therapeutic manipulation of S6K1 and AMPK might mimic CR and could provide broad protection against diseases of aging.
机译：热量限制（CR）可以防止衰老和疾病，但是影响哺乳动物寿命的机制尚不清楚。我们在小鼠中发现，核糖体S6蛋白激酶1（S6K1）的缺失是营养应答性mTOR（雷帕霉素的哺乳动物靶标）信号传导途径的组成部分，导致寿命延长和对与年龄相关的疾病（例如骨骼）的抵抗力免疫，运动功能障碍和胰岛素敏感性丧失。 S6K1诱导的基因表达模式的删除类似于在CR中观察到的或通过药理学激活的磷酸腺苷单磷酸（AMP）激活的蛋白激酶（AMPK）（一种保守的CR代谢反应调节剂）。我们的结果表明，S6K1影响健康的哺乳动物寿命，并表明S6K1和AMPK的治疗性操作可能模仿CR，并可以提供抵抗衰老疾病的广泛保护。

著录项

  • 来源
    《Science》 |2009年第5949期|140-144|共5页
  • 作者

    Colin Selman; Jennifer M. A. Tutlet; Daniela Wieser; Elaine Irvine; Steven J. Lingard; Agharul I. Choudhury; Marc Claret; Hind Al-Qassab; Danielle Carmignac; Faruk Ramadani; Angela Woods; lain C. A. Robinson; Eugene Schuster; Rachel L. Batterham; Sara C. Kozma; George Thomas; David Carling; Klaus Okkenhaug; Janet M. Thornton; Linda Partridge; David Gems; Dominic J. Withers;

  • 作者单位

    Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen AB24 2TZ, UK;

    Institute of Healthy Ageing, Department of Genetics, Evolution and Environment, University College London, London WC1E 6BT, UK;

    European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK;

    Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK;

    Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK;

    Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK;

    Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK;

    Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK;

    Division of Molecular Neuroendocrinology, Medical Research Council National Institute for Medical Research, London NW7 1AA, UK;

    Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Cambridge CB22 3AT, UK;

    Cellular Stress Group, Medical Research Council Clinical Sciences Centre, Imperial College, London W12 0NN, UK;

    Division of Molecular Neuroendocrinology, Medical Research Council National Institute for Medical Research, London NW7 1AA, UK;

    European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK;

    Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK;

    Department of Cancer and Cell Biology, Genome Research Institute, University of Cincinnati, Cincinnati, OH 45237, USA;

    Department of Cancer and Cell Biology, Genome Research Institute, University of Cincinnati, Cincinnati, OH 45237, USA;

    Cellular Stress Group, Medical Research Council Clinical Sciences Centre, Imperial College, London W12 0NN, UK;

    Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Cambridge CB22 3AT, UK;

    European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK;

    Institute of Healthy Ageing, Department of Genetics, Evolution and Environment, University College London, London WC1E 6BT, UK;

    Institute of Healthy Ageing, Department of Genetics, Evolution and Environment, University College London, London WC1E 6BT, UK;

    Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK Metabolic Signaling Group, Medical Research Council Clinical Sciences Centre, Imperial College, London W12 0NN, UK;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

  • 入库时间 2022-08-18 02:54:55

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号