Will Epothilone Write An Epitaph for Cancer?

摘要

The current Hot Ten contains three papers on the same subject: #6, 7, and 10 report the synthesis of epothilone, the forerunner of a new class of anticancer drugs, and ones that can deal with drug-resistant cell lines for breast and colon cancers. Could this compound, or one of its derivatives, possibly repeat the success of the taxol anticancer treatments now in use?