Toxicity Testing in the 21st Century

摘要

This month's lead is a summary and review of the National Research Council's "Toxicity Testing in the 21st Century: A Vision and A Strategy."1 In this article, Daniel Krewski, Melvin Andersen, Ellen Mantus, and Lauren Zeise summarize a vision to advance toxicity testing and human health assessment of environmental agents. They describe how scientific advances can transform toxicity testing to allow additional assessments of potentially toxic chemicals by using more timely and more cost-effective methods, including high- and medium-throughput in vitro screening assays, computational toxicology and systems biology, along with other emerging high-content testing methodologies, such as functional ge-nomics and transcriptomics.