Up-regulation of IL-23p19 expression in rheumatoid arthritis synovial fibroblasts by IL-17 through PI3-kinase-, NF-κB- and p38 MAPK-dependent signalling pathways

H.-R. Kim; M.-L. Cho; K.-W. Kim; J.-Y. Juhn; S.-Y. Hwang; C.-H. Yoon; S.-H. Park; S.-H. Lee; and H.-Y. Kim

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Up-regulation of IL-23p19 expression in rheumatoid arthritis synovial fibroblasts by IL-17 through PI3-kinase-, NF-κB- and p38 MAPK-dependent signalling pathways

机译：IL-17通过PI3激酶，NF-κB-和p38 MAPK依赖性信号通路上调类风湿关节炎滑膜成纤维细胞中IL-23p19的表达

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Objective. To investigate the expression of interleukin (IL)-23p19 in human rheumatoid arthritis (RA) synovial fibroblasts and its up-regulation by IL-17 stimulation, and to define the signal pathways involved in the regulation of IL-23p19 expression in RA synovial fibroblasts.

机译：目的。研究白细胞介素（IL）-23p19在类风湿性关节炎（RA）滑膜成纤维细胞中的表达及其通过IL-17刺激的上调，并确定涉及调控RA滑膜成纤维细胞中IL-23p19表达的信号途径。

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《Rheumatology》 |2007年第1期|57-64|共8页
作者
H.-R. Kim; M.-L. Cho; K.-W. Kim; J.-Y. Juhn; S.-Y. Hwang; C.-H. Yoon; S.-H. Park; S.-H. Lee; and H.-Y. Kim;
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Department of Internal Medicine School of Medicine Konkuk University Seoul and;

Rheumatism Research Center Catholic Institutes of Medical Science The Catholic University of Korea Seoul and;

Graduate School of Biology and Information Technology Institute of Genetic Engineering Hankyung National University Ansung Kyonggi-Do Korea.;

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1. Up-regulation of IL-23p19 expression in rheumatoid arthritis synovial fibroblasts by IL-17 through PI3-kinase-, NF-kappaB- and p38 MAPK-dependent signalling pathways. [J] . Kim HR, Cho ML, Kim KW, Rheumatology . 2007,第1期

机译：IL-17通过PI3激酶，NF-κB和p38 MAPK依赖性信号通路上调类风湿关节炎滑膜成纤维细胞中IL-23p19的表达。
2. IL-17 induces production of IL-6 and IL-8 in rheumatoid arthritis synovial fibroblasts via NF-κB- and PI3-kinase/Akt-dependent pathways [J] . Sue-Yun Hwang, Ju-Young Kim, Kyoung-Woon Kim, Arthritis Research . 2004,第2期

机译：IL-17通过NF-κB和PI3激酶/ Akt依赖性途径诱导类风湿关节炎滑膜成纤维细胞中IL-6和IL-8的产生
3. CXCL16 upregulates RANKL expression in rheumatoid arthritis synovial fibroblasts through the JAK2/STAT3 and p38/MAPK signaling pathway [J] . Li Chang-hong, Xu Lin-lin, Zhao Jin-xia, Inflammation research: Official journal of the European Histamine Research Society . 2016,第3期

机译：CXCL16通过JAK2 / STAT3和p38 / MAPK信号通路上调类风湿关节炎滑膜成纤维细胞中RANKL的表达
4. Modulation of the immune response via the NF-κB signaling pathway in rheumatoid arthritis in vitro models [C] . Patricia R. Wardwell, Rebecca A. Bader Society for Biomaterials annual meeting and exposition . 2015

机译：类风湿关节炎体外模型中通过NF-κB信号通路调节免疫应答
5. Regulation of Tumor Necrosis Factor-alpha Signaling in Rheumatoid Arthritis Synovial Fibroblasts by Green Tea Polyphenol Epigallocatechin-3-gallate. [D] . Riegsecker, Sharayah. 2013

机译：绿茶多酚表没食子儿茶素-3-没食子酸酯对类风湿关节炎滑膜成纤维细胞中肿瘤坏死因子-α信号的调节。
6. IL-17 induces production of IL-6 and IL-8 in rheumatoid arthritis synovial fibroblasts via NF-κB- and PI3-kinase/Akt-dependent pathways [O] . Sue-Yun Hwang, Ju-Young Kim, Kyoung-Woon Kim, 2004

机译：IL-17通过NF-κB-和PI3-激酶/ Akt依赖性途径诱导类风湿关节炎滑膜成纤维细胞中IL-6和IL-8的产生
7. Up-regulation of IL-23p19 expression in rheumatoid arthritis synovial fibroblasts by IL-17 through PI3-kinase-, NF- B- and p38 MAPK-dependent signalling pathways [O] . H.-R. Kim, M.-L. Cho, K.-W. Kim, 2007

机译：IL-17通过PI3-激酶，NF-B和P38依赖信号通路IL-17中类风湿性关节炎滑膜成纤维细胞中的IL-23P19表达的上调

Up-regulation of IL-23p19 expression in rheumatoid arthritis synovial fibroblasts by IL-17 through PI3-kinase-, NF-κB- and p38 MAPK-dependent signalling pathways

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