And its use gene expression signatures related to WNT / B- catenin signaling pathway

摘要

The present invention relates to a novel set of 16 biomarkers, microarrays that provide for the detection thereof, an expression signature comprising 16 genes or a subset thereof, and the use thereof in determining the regulation status of Wnt/&bgr;-catenin signaling pathway. The regulation status of Wnt/&bgr;-catenin signaling pathway may be assayed based on the level of expression of one or more of these genes. The expression of these biomarkers may be used to evaluate Wnt/&bgr;-catenin pathway deregulation status; classify a cell sample as having a deregulated or regulated Wnt/&bgr;-catenin signaling pathway; determine whether an agent modulates the Wnt/&bgr;-catenin signaling pathway; predict response of a subject to an agent that modulates the Wnt/&bgr;-catenin signaling pathway; assign treatment to a subject; or evaluate the pharmacodynamic effects of therapies designed to regulate Wnt/&bgr;-catenin pathway signaling.