MicroRNA-21 as Therapeutic Target in Cancer and Cardiovascular Disease

摘要

Abstract: MicroRNAs (miRNAs) are a broad class of small non-coding RNAs that control expression of complementary ntarget messenger RNAs. Dysregulation of miRNAs has been described in various disease states including cancer and ncardiac disease. A particular miRNA that was consistently reported to be upregulated in both cancer and various forms of ncardiovascular diseases is miR-21. MiR-21 exerts oncogenic activity and therefore is considered as an oncomir. In the ncardiovascular system miR-21 is enriched in fibroblasts and contributes to the development of fibrosis and heart failure. nMiR-21 therefore emerges as an interesting candidate for the development of therapeutic strategies against many forms of ncancer as well as heart diseases. Indeed, treatment with anti-miR-21 oligonucleotides reduced breast cancer growth. nInhibition of miR-21 by synthetic miRNA antagonists (antagomirs) improved heart function in a cardiac disease model. nThe same beneficial effects were observed in miR-21 knockout mice subjected to pressure-overload of the left ventricle nunderlining the key role of miR-21 as a therapeutic target. We here overview the current patent situation about the ntherapeutic use of miR-21 modulation in cancer and cardiovascular disease.