Synthesis of polyethylene glycol supported chiral monosulfonamide and its application in asymmetric transfer hydrogenation of prochiral ketones

摘要

A new polyethylene glycol supported chiral monosulfonamide was conveniently synthesized from (R,R)-1,2-diphenylethylenediamine. The ruthenium catalyst prepared from polyethylene glycol supported chiral monosulfonamide with [RuCl₂(p-cymene)]₂ was used in the asymmetric transfer hydrogenation of prochiral ketones in neat water with good to excellent conversions and enantioselectivities. The catalyst could be easily recovered and reused several times.