DOSE-RESPONSE CURVE FOR TRANSLOCATION FREQUENCY WITH A SINGLE PAIR OF PAINTED CHROMOSOMES: A COMPARISON WITH DICENTRIC AND MICRONUCLEI FREQUENCY

摘要

A translocation dose-response curve using a single pair of painted chromosomes was constructed. The translocation frequencies observed at different doses were compared to those obtained for dicentrics (DC) and micronuclei (MN). The translo- cation and DC frequency followed the Poisson distribution and MN showed over-dispersion. The translocation and DC frequencies were nearly the same for each dose point. Micronuclei showed a comparatively lower frequency. The α/β ratio for translocations (0.916) and DC (0.974) were comparable, whereas the value for MN (1.526) was much higher. The equal frequencies of translo- cations and DC observed for a given dose indicated that genomic translocation frequency estimated using a single pair of painted chromosomes provides a reliable and easy method to measure translocation frequency.