The relationship between elevated fibrinogen and markers of infection; a comparison of seasonal cycles

摘要

To test the hypothesis that higher levels of fibrinogen in winter are related to infections via the acute phase response, we assessed seasonal variation in fibrinogen and C-reactive protein, together with three other responses to infection: white cell count, human herpesvirus-6 IgG anti- body and interleukin-6. Monthly blood samples from 24 subjects aged 75+ years were assessed for fibrinogen, c-reactive protein, white cell count, and human herpesvirus-6 IgG antibody.