Is there evidence for exogenous risk factors in the aetiology and spread of Creutzfeldt-Jakob disease?

摘要

The hypothesis that spCJD is caused solely by genetic abnormalities leading to a spontaneous mutation of prion protein, favoured in the 1980s, looks increasingly incomplete. As predicted by Matthews in 1979, reservoirs of infection, notably Zoonotic, may well exist and a perhaps a smaller Number of cases are caused through iatrogenic and Person-to-person contact.