Anxiolytic effects of a novel group II metabotropic glutamate receptor agonist (LY354740) in the fear-potentiated startle paradigm in humans

Christian Grillon; Jeremy Cordova; Louise R. Levine; Charles A. Morgan; III

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Anxiolytic effects of a novel group II metabotropic glutamate receptor agonist (LY354740) in the fear-potentiated startle paradigm in humans

机译：新型II型代谢型谷氨酸受体激动剂（LY354740）在人类恐惧增强惊吓范式中的抗焦虑作用

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摘要

LY354740, a structural analogue of glutamate that shows specificity at the mGluR2/3 receptor, has anxiolytic effects in animal models.

机译：LY354740是谷氨酸的结构类似物，对mGluR2 / 3受体具有特异性，在动物模型中具有抗焦虑作用。

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来源
《Psychopharmacology》 |2003年第4期|446-454|共9页
作者
Christian Grillon; Jeremy Cordova; Louise R. Levine; Charles A. Morgan; III;
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作者单位

NIMH/NIH/DHHS Mood and Anxiety Disorder Program;

Connecticut VA Medical Center;

Lilly Research Laboratories Lilly Corporate Center Eli Lilly and Company;

Connecticut VA Medical Center;

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原文格式 PDF
正文语种 eng
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关键词
Glutamate; LY354740; Fear; Anxiolytic; Fear-potentiated startle; Darkness;

机译：谷氨酸;LY354740;恐惧;抗焦虑;恐惧增强的惊吓;黑暗;

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1. Anxiolytic effects of a novel group II metabotropic glutamate receptor agonist (LY354740) in the fear-potentiated startle paradigm in humans. [J] . Grillon C, Cordova J, Levine LR, Psychopharmacology . 2003,第4期

机译：新型II型代谢型谷氨酸受体激动剂（LY354740）在人的恐惧增强惊吓范式中的抗焦虑作用。
2. Preliminary evidence of attenuation of the disruptive effects of the NMDA glutamate receptor antagonist, ketamine, on working memory by pretreatment with the group II metabotropic glutamate receptor agonist, LY354740, in healthy human subjects. [J] . Krystal JH, Abi Saab W, Perry E, Psychopharmacology . 2005,第1期

机译：通过在健康的人类受试者中进行II类代谢型谷氨酸受体激动剂LY354740的预处理，可以减轻NMDA谷氨酸受体拮抗剂氯胺酮对工作记忆的破坏作用的初步证据。
3. Preliminary evidence of attenuation of the disruptive effects of the NMDA glutamate receptor antagonist, ketamine, on working memory by pretreatment with the group II metabotropic glutamate receptor agonist, LY354740, in healthy human subjects [J] . John H. Krystal, Walid Abi-Saab, Edward Perry, Psychopharmacology . 2005,第1期

机译：在健康的人类受试者中，通过II组代谢型谷氨酸受体激动剂LY354740预处理，可以减轻NMDA谷氨酸受体拮抗剂氯胺酮对工作记忆的破坏作用的初步证据。
4. Inverse agonists to explore the mechanisms of metabotropic glutamate receptor activity [C] . L. Prezeau, M.L. Parmentier, R Carroll, Fundaci髇 Dr. Antonio Esteve . 2003

机译：反向激动剂探讨代谢谷氨酸受体活性的机制
5. Role of the Group I metabotropic glutamate receptors in prepulse inhibition of the startle response. [D] . Brody, Suzanne Amy. 2003

机译：I组代谢型谷氨酸受体在惊吓反应的脉冲前抑制中的作用。
6. Selective agonist of group II glutamate metabotropic receptors LY354740 inhibits tolerance to analgesic effects of morphine in mice [O] . Piotr Popik, Ewa Kozela, Andrzej Pilc 2000

机译：II型谷氨酸代谢型受体选择性激动剂LY354740抑制吗啡对小鼠镇痛作用的耐受性
7. Anxiolytic effects of a novel group II metabotropic glutamate receptor agonist (LY354740) in the fear-potentiated startle paradigm in humans [O] . Christian Grillon, Jeremy Cordova, Louise R. Levine, 2003

机译：一种新型II族代谢谷氨酸受体激动剂（LY354740）在人类恐惧促进的惊吓范式中的抗焦虑作用
8. Group II Metabotropic Glutamate Receptors as Potential Pharmaceutical Targets for Neurofibroma Formation [R] . Stern, M. 2011

机译：第II组代谢型谷氨酸受体作为神经纤维瘤形成的潜在药物靶标

Anxiolytic effects of a novel group II metabotropic glutamate receptor agonist (LY354740) in the fear-potentiated startle paradigm in humans

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