Muir--Torre-like syndrome in Fhit-deficient mice

摘要

To investigate the role of the Fhit gene in carcinogen induction of neoplasia. we have inactivated one Fhit allele in mouse embryonic stem cells and produced (129/SvJ x C57BL/6J) F_1 mice with a Fhit allele inactivated (+/-). Fhit +/+ and +/- mice were treated intragastrically with nitrosomethylbenzylamine and observed for 10 wk posttreatment. A total of 25/100 of the +/+ mice developed adenoma or papilloma of the forestomach. whereas 100/100 of the +/- mice developed multiple tumors that were a mixture of adenomas. squamous papillomas, invasive carcinomas of the fore- stomach, as well as tumors of sebaceous glands. The visceral and sebaceous tumors, which lacked Fhit protein. were similar to those characteristic of Muir-Torre familial cancer syndrome.