The Toll-like syndrome - Muir in Fhit-deficient mice

摘要

The present invention provides a non-human transgenic animal having a FHIT gene that has been destroyed. The present invention further provides a transgenic mouse that one or both of the Fhit allele has been inactivated. The Fhit-deficient mice, Muir - it was similar to Thor familial cancer syndrome, to develop tumors of multiple species of origin of both of the sebaceous glands and internal organs are preferred. In addition, the production of these transgenic mice, and cancer (preferably, Muir - gastrointestinal cancer Toll syndrome is included in a part of) the present invention is the influence of carcinogenic factors in the promotion of clonal proliferation of neoplastic cells of their use as model systems thereof for the study. In addition, cancer (preferably, gastrointestinal cancer) The present invention relates to testing therapeutic agents for efficacy in the treatment and prevention.