Overcoming retinoic acid-resistance of mammary carcinomas by diverting retinoic acid from PPARβ/δ to RAR

Thaddeus T. Schug; Daniel C. Berry; Illia A. Toshkov; Le Cheng; Alexander Yu Nikitin; Noa Noy

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Overcoming retinoic acid-resistance of mammary carcinomas by diverting retinoic acid from PPARβ/δ to RAR

机译：通过将视黄酸从PPARβ/δ转移至RAR来克服乳腺癌的视黄酸耐药性

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Retinoic acid (RA) displays potent anticarcinogenic activities that are mediated by the nuclear retinoic acid receptors (RARs). However, use of RA in oncology is limited by RA resistance acquired during carcinogenesis. Moreover, in some cancers, RA facili

机译：维甲酸（RA）显示出强大的抗癌活性，这些活性是由核维甲酸受体（RAR）介导的。但是，RA在肿瘤学中的应用受到致癌过程中获得的RA抗性的限制。此外，在某些癌症中，RA facili

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来源
《Proceedings of the National Academy of Sciences of the United States of America》 |2008年第21期|7546-7551|共6页
作者
Thaddeus T. Schug; Daniel C. Berry; Illia A. Toshkov; Le Cheng; Alexander Yu Nikitin; Noa Noy;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类
关键词
cancer; lipid-bindinq proteins; nuclear receptors; CRABP; FABP;

机译：癌症;脂质-bindinq蛋白;核受体CRABP;财务会计准则;
入库时间 2022-08-18 00:43:30

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1. Direct Channeling of Retinoic Acid between Cellular Retinoic Acid-Binding Protein II and Retinoic Acid Receptor Sensitizes Mammary Carcinoma Cells to Retinoic Acid-Induced Growth Arrest [J] . Anuradha S. Budhu, Noa Noy Molecular and Cellular Biology . 2002,第8期

机译：视黄酸在细胞视黄酸结合蛋白II和视黄酸受体之间的直接通道使乳癌细胞敏感，以视黄酸诱导的生长停滞
2. Retinoic Acid Induces Neurogenesis by Activating Both Retinoic Acid Receptors (RARs) and Peroxisome Proliferator-activated Receptor β/δ (PPARβ/δ) [J] . Shuiliang Yu, Liraz Levi, Ruth Siegel, The Journal of biological chemistry . 2012,第50期

机译：通过活化视黄酸受体（RARS）和过氧化物体增殖物激活的受体β/δ（PPARβ/δ），视黄酸诱导神经发生。（PPARβ/δ）
3. Synergistic activation of retinoic acid (RA)-responsive genes and induction of embryonal carcinoma cell differentiation by an RA receptor alpha (RAR alpha)-, RAR beta-, or RAR gamma-selective ligand in combination with a retinoid X receptor-specific ligand. [J] . B Roy, R Taneja, P Chambon Molecular and Cellular Biology . 1995,第12期

机译：视黄酸（RA）响应基因的协同激活和RA受体α（RAR alpha）-，RARβ-或RARγ-选择性配体与类视黄醇X受体特异性配体的组合诱导胚胎癌细胞分化。
4. TOWARDS THE IDENTIFICATION OF THE CRABP II AND RAR REGIONS INVOLVED IN RETINOIC ACID TRANSFER USING HDX [C] . Virginie Sjoelund, Igor A. Kaltashov ASMS Conference on Mass Spectrometry and Allied Topics . 2008

机译：朝向使用HDX参与视黄酸转移的Crabp II和RAR区域的鉴定
5. Ethanol (EtOH)-Mediated Differentiation of Embryonic Stem Cells via Retinoic Acid (RA)-Retinoic Acid Receptor-Gamma (RARγ) Signaling [D] . Serio, Ryan Neil. 2019

机译：乙醇（EtOH）通过视黄酸（RA）-视黄酸受体-γ（RARγ）信号介导的胚胎干细胞分化
6. Overcoming retinoic acid-resistance of mammary carcinomas by diverting retinoic acid from PPARβ/δ to RAR [O] . Thaddeus T. Schug, Daniel C. Berry, Illia A. Toshkov, 2008

机译：通过将视黄酸从PPARβ/δ转移至RAR来克服乳腺癌的视黄酸耐药性
7. Overcoming retinoic acid-resistance of mammary carcinomas by diverting retinoic acid from PPARβ/δ to RAR [O] . Schug, Thaddeus T., Berry, Daniel C., Toshkov, Illia A., 2008

机译：通过将视黄酸从PPARβ/δ转移至RAR来克服乳癌的视黄酸耐药性

Overcoming retinoic acid-resistance of mammary carcinomas by diverting retinoic acid from PPARβ/δ to RAR

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